Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study.
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Authors
Revier, Camice J
Reininghaus, Ulrich
Dutta, Rina
Fearon, Paul
Murray, Robin M
Doody, Gillian A
Croudace, Tim
Dazzan, Paola
Heslin, Margaret
Onyejiaka, Adanna
Issue Date
2015-May
Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described.
Description
Citation
Revier, C. J., Reininghaus, U., Dutta, R., Fearon, P., Murray, R. M., Doody, G. A., Croudace, T., Dazzan, P., Heslin, M., Onyejiaka, A., Kravariti, E., Lappin, J., Lomas, B., Kirkbride, J. B., Donoghue, K., Morgan, C., & Jones, P. B. (2015). Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study. The Journal of nervous and mental disease, 203(5), 379–386. https://doi.org/10.1097/NMD.0000000000000295
Publisher
License
Journal
The Journal of nervous and mental disease
Volume
203
Issue
5
PubMed ID
ISSN
1539-736X