Grey matter abnormalities in first-episode schizophrenia and affective psychosis.
Authors
Morgan, Kevin D
Dazzan, Paola
Orr, Kenneth G
Hutchinson, Gerard
Chitnis, Xavier
Suckling, John
Lythgoe, David
Pollock, Sarah-Jayne
Rossell, Susan
Shapleske, Jane
Issue Date
2007-Dec
Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
Grey matter and other structural brain abnormalities are consistently reported in first-onset schizophrenia, but less is known about the extent of neuroanatomical changes in first-onset affective psychosis.
To determine which brain abnormalities are specific to (a) schizophrenia and (b) affective psychosis.
We obtained dual-echo (proton density/T2-weighted) magnetic resonance images and carried out voxel-based analysis on the images of 73 patients with first-episode psychosis (schizophrenia n=44, affective psychosis n=29) and 58 healthy controls.
Both patients with schizophrenia and patients with affective psychosis had enlarged lateral and third ventricle volumes. Regional cortical grey matter reductions (including bilateral anterior cingulate gyrus, left insula and left fusiform gyrus) were evident in affective psychosis but not in schizophrenia, although patients with schizophrenia displayed decreased hippocampal grey matter and increased striatal grey matter at a more liberal statistical threshold.
Both schizophrenia and affective psychosis are associated with volumetric abnormalities at the onset of frank psychosis, with some of these evident in common brain areas.
To determine which brain abnormalities are specific to (a) schizophrenia and (b) affective psychosis.
We obtained dual-echo (proton density/T2-weighted) magnetic resonance images and carried out voxel-based analysis on the images of 73 patients with first-episode psychosis (schizophrenia n=44, affective psychosis n=29) and 58 healthy controls.
Both patients with schizophrenia and patients with affective psychosis had enlarged lateral and third ventricle volumes. Regional cortical grey matter reductions (including bilateral anterior cingulate gyrus, left insula and left fusiform gyrus) were evident in affective psychosis but not in schizophrenia, although patients with schizophrenia displayed decreased hippocampal grey matter and increased striatal grey matter at a more liberal statistical threshold.
Both schizophrenia and affective psychosis are associated with volumetric abnormalities at the onset of frank psychosis, with some of these evident in common brain areas.
Description
Citation
Morgan, K. D., Dazzan, P., Orr, K. G., Hutchinson, G., Chitnis, X., Suckling, J., Lythgoe, D., Pollock, S. J., Rossell, S., Shapleske, J., Fearon, P., Morgan, C., David, A., McGuire, P. K., Jones, P. B., Leff, J., & Murray, R. M. (2007). Grey matter abnormalities in first-episode schizophrenia and affective psychosis. The British journal of psychiatry. Supplement, 51, s111–s116. https://doi.org/10.1192/bjp.191.51.s111
Publisher
License
Journal
The British journal of psychiatry. Supplement
Volume
51
Issue
PubMed ID
ISSN
0960-5371