Neuropsychological functioning in first-episode schizophrenia.
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Authors
Kravariti, Eugenia
Morgan, Kevin
Fearon, Paul
Zanelli, Jolanta W
Lappin, Julia M
Dazzan, Paola
Morgan, Craig
Doody, Gillian A
Harrison, Glynn
Jones, Peter B
Issue Date
2009-Oct
Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
Identifying neurocognitive subtypes in schizophrenia may help establish neurobiologically meaningful subtypes of the disorder, but is frequently confounded by differences in intellectual function between individuals with schizophrenia and controls.
To examine neuropsychological performance in individuals with epidemiologically based, first-onset schizophrenia and intellectually matched controls.
Using standard IQ and reading tests, we examined the proportions of 101 people with epidemiologically derived, first-onset schizophrenia/schizoaffective disorder and 317 community controls, falling into three a priori defined intellectual categories: 'stable good', 'deteriorated poor' and 'stable poor'. Neuropsychological function was compared between intellectually matched participants with schizophrenia and control subgroups.
Multiple deficits in executive function, processing speed and verbal memory, but not visual/spatial perception/memory, were detected in all participant groups with schizophrenia compared with controls. The average effect size across the affected domains ranged from small to medium to large in the stable good, deteriorated poor and stable poor subgroups of participants with schizophrenia, respectively.
Compared with intellectually matched controls, people with epidemiologically derived, first-onset schizophrenia/schizoaffective disorder show multiple deficits in executive function, processing speed and verbal memory.
To examine neuropsychological performance in individuals with epidemiologically based, first-onset schizophrenia and intellectually matched controls.
Using standard IQ and reading tests, we examined the proportions of 101 people with epidemiologically derived, first-onset schizophrenia/schizoaffective disorder and 317 community controls, falling into three a priori defined intellectual categories: 'stable good', 'deteriorated poor' and 'stable poor'. Neuropsychological function was compared between intellectually matched participants with schizophrenia and control subgroups.
Multiple deficits in executive function, processing speed and verbal memory, but not visual/spatial perception/memory, were detected in all participant groups with schizophrenia compared with controls. The average effect size across the affected domains ranged from small to medium to large in the stable good, deteriorated poor and stable poor subgroups of participants with schizophrenia, respectively.
Compared with intellectually matched controls, people with epidemiologically derived, first-onset schizophrenia/schizoaffective disorder show multiple deficits in executive function, processing speed and verbal memory.
Description
Citation
Kravariti, E., Morgan, K., Fearon, P., Zanelli, J. W., Lappin, J. M., Dazzan, P., Morgan, C., Doody, G. A., Harrison, G., Jones, P. B., Murray, R. M., & Reichenberg, A. (2009). Neuropsychological functioning in first-episode schizophrenia. The British journal of psychiatry : the journal of mental science, 195(4), 336–345. https://doi.org/10.1192/bjp.bp.108.055590
Publisher
License
Journal
The British journal of psychiatry : the journal of mental science
Volume
195
Issue
4
PubMed ID
ISSN
1472-1465