The structural brain correlates of neurological soft signs in healthy individuals.
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Authors
Dazzan, Paola
Morgan, Kevin D
Chitnis, Xavier
Suckling, John
Morgan, Craig
Fearon, Paul
McGuire, Philip K
Jones, Peter B
Leff, Julian
Murray, Robin M
Issue Date
2005-10-26
Type
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Journal Article
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
It has yet to be established whether neurological soft signs (NSS), which include poor motor coordination, sensory perceptual difficulties and difficulties in sequencing of complex motor tasks, result from specific or diffuse brain structural abnormalities. Studying the neuroanatomical basis of NSS in healthy individuals may help to identify which brain areas are specifically associated with these signs, while excluding the potential confounding effects of psychiatric and neurological disorders. We investigated the relationship between brain structure and NSS in 43 healthy individuals, using the Neurological Evaluation Scale for neurological assessment, and high resolution MRI and voxel-based methods of image analysis to investigate brain structure. Higher rates of NSS were associated with a reduction of inferior frontal gyrus, middle and superior temporal gyrus, and anterior cingulate gyrus. It is of note that in a previous study of patients with psychosis we found that an excess of NSS was associated with a reduction of similar cortical areas. Therefore, we suggest that these cortical brain structural changes represent a common neuroanatomical substrate of NSS, across healthy individuals and patients with psychosis.
Description
Citation
Dazzan, P., Morgan, K. D., Chitnis, X., Suckling, J., Morgan, C., Fearon, P., McGuire, P. K., Jones, P. B., Leff, J., & Murray, R. M. (2006). The structural brain correlates of neurological soft signs in healthy individuals. Cerebral cortex (New York, N.Y. : 1991), 16(8), 1225–1231. https://doi.org/10.1093/cercor/bhj063
Publisher
License
Journal
Cerebral cortex (New York, N.Y. : 1991)
Volume
16
Issue
8
PubMed ID
ISSN
1047-3211