A preliminary study of baclofen-induced growth hormone release in generalised social phobia.
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Authors
Condren, Rita M
Lucey, Jim V
Thakore, Jogin H
Issue Date
2003-Mar
Type
Clinical Trial
Journal Article
Journal Article
Language
en
Keywords
Alternative Title
Abstract
The authors sought to examine central GABA(B) receptor responses in patients with generalised social phobia using the growth hormone (GH) response to baclofen.
Baclofen 20 mg was administered to 15 patients and 15 healthy matched controls and plasma growth hormone was monitored over a 3 h period.
The GH response in patients was significantly reduced in comparison to that of controls when calculated as both area under the curve (AUC) and delta (Delta) response.
The results suggest an abnormality of central GABA(B) receptor function in this disorder.
Baclofen 20 mg was administered to 15 patients and 15 healthy matched controls and plasma growth hormone was monitored over a 3 h period.
The GH response in patients was significantly reduced in comparison to that of controls when calculated as both area under the curve (AUC) and delta (Delta) response.
The results suggest an abnormality of central GABA(B) receptor function in this disorder.
Description
Citation
Condren RM, Lucey JV, Thakore JH. A preliminary study of baclofen-induced growth hormone release in generalised social phobia. Hum Psychopharmacol. 2003 Mar;18(2):125-30. doi: 10.1002/hup.443. PMID: 12590406.
Publisher
License
Copyright 2002 John Wiley & Sons, Ltd.
Journal
Human psychopharmacology
Volume
18
Issue
2
PubMed ID
DOI
ISSN
0885-6222