Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis.
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Authors
Lappin, Julia M
Dazzan, Paola
Morgan, Kevin
Morgan, Craig
Chitnis, Xavier
Suckling, John
Fearon, Paul
Jones, Peter B
Leff, Julian
Murray, Robin M
Issue Date
2007-Dec
Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
First-episode psychosis is typically preceded by a prodrome in which there is deterioration in global and social functioning.
To examine whether the duration of the prodromal phase influences grey and white matter volumes at the onset of psychosis.
Eighty-two people were scanned using magnetic resonance imaging when they developed a first episode of psychosis. The duration of the prodromal phase was estimated from detailed interviews and medical records. Voxel-based morphometry was used to assess neuroanatomical abnormalities.
A long prodromal phase was associated with smaller grey matter volumes in the cingulate, frontal and left insular cortex, and with less white matter volume bilaterally in the superior longitudinal and uncinate fasciculi and the cingulum.
The severity of volumetric abnormalities in first-episode psychosis was greater in those with a long prodrome.
To examine whether the duration of the prodromal phase influences grey and white matter volumes at the onset of psychosis.
Eighty-two people were scanned using magnetic resonance imaging when they developed a first episode of psychosis. The duration of the prodromal phase was estimated from detailed interviews and medical records. Voxel-based morphometry was used to assess neuroanatomical abnormalities.
A long prodromal phase was associated with smaller grey matter volumes in the cingulate, frontal and left insular cortex, and with less white matter volume bilaterally in the superior longitudinal and uncinate fasciculi and the cingulum.
The severity of volumetric abnormalities in first-episode psychosis was greater in those with a long prodrome.
Description
Citation
Lappin, J. M., Dazzan, P., Morgan, K., Morgan, C., Chitnis, X., Suckling, J., Fearon, P., Jones, P. B., Leff, J., Murray, R. M., & McGuire, P. K. (2007). Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis. The British journal of psychiatry. Supplement, 51, s123–s127. https://doi.org/10.1192/bjp.191.51.s123
Publisher
License
Journal
The British journal of psychiatry. Supplement
Volume
51
Issue
PubMed ID
ISSN
0960-5371