Blood cell ratios in mood and cognitive outcomes following electroconvulsive therapy.
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Authors
Ryan, Karen M
Lynch, Marie
McLoughlin, Declan M
Issue Date
2022-11-16
Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Language
en
Keywords
Depression , Electroconvulsive therapy , MLR , NLR , PLR , SII
Alternative Title
Abstract
Systemic inflammation is commonly reported in depression, with dysregulation of both the innate and adaptive arms of the immune system documented. Obtaining ratios of neutrophils, platelets, and monocytes to counts of lymphocytes (NLR, PLR, MLR, respectively) represents a low-cost and easily reproducible measure of an individual's inflammatory burden that can be calculated effortlessly from routine clinical full white blood cell counts. Electroconvulsive therapy (ECT) remains the most effective acute antidepressant treatment for depression but is often limited by its cognitive side-effects. Here, we examined differences in blood cell ratios in subgroups of depressed patients (unipolar/bipolar, psychotic/non-psychotic, early-onset/late-onset) and ECT-related subgroups (responder/non-responder, remitter/non-remitter). We also explored the relationships between blood cell ratios and depression severity and immediate cognitive outcomes post-ECT. Our results show baseline NLR was raised in patients with psychotic depression. In the entire group of patients, significant negative correlations were noted between the PLR and SII and baseline HAM-D24 score, signifying that lower systemic inflammation is associated with more severe depressive symptoms. Significant positive correlations were noted between various blood cell ratios and mean time to recovery of orientation in the entire group of patients and in depression subgroups, indicating that increased peripheral inflammation is linked to worse cognitive outcomes post-ECT. Overall, our results suggest that assessment of blood cell ratios could be useful for predicting mood changes in patients at risk of developing depressive episodes or relapse following successful treatment or for identifying those at risk for cognitive side-effects following ECT.
Description
Citation
Ryan, K. M., Lynch, M., & McLoughlin, D. M. (2022). Blood cell ratios in mood and cognitive outcomes following electroconvulsive therapy. Journal of psychiatric research, 156, 729–736. https://doi.org/10.1016/j.jpsychires.2022.11.016
Publisher
License
Copyright © 2022 Elsevier Ltd. All rights reserved.
Journal
Journal of psychiatric research
Volume
156
Issue
PubMed ID
ISSN
1879-1379