Gray matter abnormalities associated with duration of untreated psychosis.
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Authors
Lappin, Julia M
Morgan, Kevin
Morgan, Craig
Hutchison, Gerard
Chitnis, Xavier
Suckling, John
Fearon, Paul
McGuire, Philip K
Jones, Peter B
Leff, Julian
Issue Date
2006-01-31
Type
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Journal Article
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
A long duration of untreated psychosis (DUP) is associated with relatively poor clinical and social outcomes. In order to identify whether an anatomically mediated mechanism may give rise to poorer outcomes, it is important to identify whether a long DUP is associated with greater brain structural abnormalities.
81 patients with first-episode psychosis (schizophrenia, affective, and other psychoses) were scanned using high resolution Magnetic Resonance Imaging. DUP was defined as the number of days between first onset of psychotic symptoms and first contact with mental health services. High-resolution MRI images and voxel-based methods of image analysis were used to investigate brain structure in these patients.
Longer DUP was associated with gray matter reductions in left middle and inferior temporal, left occipital and left fusiform cortices, and with gray matter excess of the left basal ganglia. All findings remained significant when co-varying for exposure to antipsychotic treatment.
Temporal gray matter reductions are more marked in patients with a long DUP. This could reflect a progressive pathological process that is active prior to treatment. Alternatively, these abnormalities could be associated with a more insidious onset of illness and a later presentation to services.
81 patients with first-episode psychosis (schizophrenia, affective, and other psychoses) were scanned using high resolution Magnetic Resonance Imaging. DUP was defined as the number of days between first onset of psychotic symptoms and first contact with mental health services. High-resolution MRI images and voxel-based methods of image analysis were used to investigate brain structure in these patients.
Longer DUP was associated with gray matter reductions in left middle and inferior temporal, left occipital and left fusiform cortices, and with gray matter excess of the left basal ganglia. All findings remained significant when co-varying for exposure to antipsychotic treatment.
Temporal gray matter reductions are more marked in patients with a long DUP. This could reflect a progressive pathological process that is active prior to treatment. Alternatively, these abnormalities could be associated with a more insidious onset of illness and a later presentation to services.
Description
Citation
Lappin, J. M., Morgan, K., Morgan, C., Hutchison, G., Chitnis, X., Suckling, J., Fearon, P., McGuire, P. K., Jones, P. B., Leff, J., Murray, R. M., & Dazzan, P. (2006). Gray matter abnormalities associated with duration of untreated psychosis. Schizophrenia research, 83(2-3), 145–153. https://doi.org/10.1016/j.schres.2005.11.018
Publisher
License
Journal
Schizophrenia research
Volume
83
Issue
2-3
PubMed ID
ISSN
0920-9964