Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients.
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Authors
Heslin, M
Lappin, J M
Donoghue, K
Lomas, B
Reininghaus, U
Onyejiaka, A
Croudace, T
Jones, P B
Murray, R M
Fearon, P
Issue Date
2016-05-26
Type
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Journal Article
Research Support, Non-U.S. Gov't
Language
en
Keywords
Depression , Outcomes , Prognosis , Psychosis , Psychotic major depression
Alternative Title
Abstract
We aimed to investigate long-term outcomes in psychotic major depression patients compared to schizophrenia and bipolar/manic psychosis patients, in an incidence sample, while accounting for diagnostic change. Based on Aetiology and Ethnicity in Schizophrenia and Other Psychoses (ÆSOP and ÆSOP-10), a first episode psychosis cohort was followed-up 10years after first presentation. The Schedules for Clinical Assessment in Neuropsychiatry, WHO Life Chart and Global Assessment of Functioning were used to assess clinical, social and service use outcomes. Seventy-two PMD patients, 218 schizophrenia patients and 70 psychotic bipolar disorder/mania patients were identified at baseline. Differences in outcome between PMD and bipolar patients based on baseline and lifetime diagnosis were minimal. Differences in clinical, social and service use outcomes between PMD and schizophrenia were more substantial with PMD patients showing better outcomes on most variables. However, there was some weak evidence (albeit not quite statistically significant at p<0.05) based on lifetime diagnoses that PMD patients were more likely to attempt suicide (OR 2.31, CI 0.98-5.42, p0.055) and self-harm (OR 2.34, CI 0.97-5.68, p0.060). PMD patients have better social and service use outcomes compared to people with schizophrenia, but may be more likely to attempt suicide or self-harm. This unique profile is important for clinicians to consider in any risk assessment.
Description
Citation
Heslin, M., Lappin, J. M., Donoghue, K., Lomas, B., Reininghaus, U., Onyejiaka, A., Croudace, T., Jones, P. B., Murray, R. M., Fearon, P., Doody, G. A., Dazzan, P., Craig, T. J., & Morgan, C. (2016). Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients. Schizophrenia research, 176(2-3), 417–422. https://doi.org/10.1016/j.schres.2016.04.049
Publisher
License
Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.
Journal
Schizophrenia research
Volume
176
Issue
2-3
PubMed ID
ISSN
1573-2509