Insight, grey matter and cognitive function in first-onset psychosis.
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Authors
Morgan, Kevin D
Dazzan, Paola
Morgan, Craig
Lappin, Julia
Hutchinson, Gerard
Suckling, John
Fearon, Paul
Jones, Peter B
Leff, Julian
Murray, Robin M
Issue Date
2010-Aug
Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
Several studies have suggested that neuropsychological and structural brain deficits are implicated in poor insight. Few insight studies however have combined neurocognitive and structural neuroanatomical measures.
Focusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis.
Voxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight.
The principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus.
The cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.
Focusing on the ability to relabel psychotic symptoms as pathological, we examined insight, brain structure and neurocognition in first-onset psychosis.
Voxel-based magnetic resonance imaging data were acquired from 82 individuals with psychosis and 91 controls assessed with a brief neuropsychological test battery. Insight was measured using the Schedule for the Assessment of Insight.
The principal analysis showed reduced general neuropsychological function was linked to poor symptom relabelling ability. A subsequent between-psychosis group analysis found those with no symptom relabelling ability had significant global and regional grey matter deficits primarily located at the posterior cingulate gyrus and right precuneus/cuneus.
The cingulate gyrus (as part of a midline cortical system) along with right hemisphere regions may be involved in illness and symptom self-appraisal in first-onset psychosis.
Description
Citation
Morgan, K. D., Dazzan, P., Morgan, C., Lappin, J., Hutchinson, G., Suckling, J., Fearon, P., Jones, P. B., Leff, J., Murray, R. M., & David, A. S. (2010). Insight, grey matter and cognitive function in first-onset psychosis. The British journal of psychiatry : the journal of mental science, 197(2), 141–148. https://doi.org/10.1192/bjp.bp.109.070888
Publisher
License
Journal
The British journal of psychiatry : the journal of mental science
Volume
197
Issue
2
PubMed ID
ISSN
1472-1465