Grey matter correlates of minor physical anomalies in the AeSOP first-episode psychosis study.
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Authors
Dean, K
Fearon, P
Morgan, K
Hutchinson, G
Orr, K
Chitnis, X
Suckling, J
Mallet, R
Leff, J
Jones, P B
Issue Date
2006-Sep
Type
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Multicenter Study
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
Minor physical anomalies are more prevalent among people with psychosis. This supports a neurodevelopmental aetiology for psychotic disorders, since these anomalies and the brain are both ectodermally derived. However, little is understood about the brain regions implicated in this association.
To examine the relationship between minor physical anomalies and grey matter structure in a sample of patients with first-episode psychosis.
Sixty patients underwent assessment of minor physical anomalies with the Lane scale. High-resolution magnetic resonance images and voxel-based methods of image analysis were used to investigate brain structure in these patients.
The total anomalies score was associated with a grey matter reduction in the prefrontal cortex and precuneus and with a grey matter excess in the basal ganglia, thalamus and lingual gyrus.
Minor physical anomalies in a sample of patients with first-episode psychosis are associated with regional grey matter changes. These regional changes may be important in the pathogenesis of psychotic disorder.
To examine the relationship between minor physical anomalies and grey matter structure in a sample of patients with first-episode psychosis.
Sixty patients underwent assessment of minor physical anomalies with the Lane scale. High-resolution magnetic resonance images and voxel-based methods of image analysis were used to investigate brain structure in these patients.
The total anomalies score was associated with a grey matter reduction in the prefrontal cortex and precuneus and with a grey matter excess in the basal ganglia, thalamus and lingual gyrus.
Minor physical anomalies in a sample of patients with first-episode psychosis are associated with regional grey matter changes. These regional changes may be important in the pathogenesis of psychotic disorder.
Description
Citation
Dean, K., Fearon, P., Morgan, K., Hutchinson, G., Orr, K., Chitnis, X., Suckling, J., Mallet, R., Leff, J., Jones, P. B., Murray, R. M., & Dazzan, P. (2006). Grey matter correlates of minor physical anomalies in the AeSOP first-episode psychosis study. The British journal of psychiatry : the journal of mental science, 189, 221–228. https://doi.org/10.1192/bjp.bp.105.016337
Publisher
License
Journal
The British journal of psychiatry : the journal of mental science
Volume
189
Issue
PubMed ID
ISSN
0007-1250