Peripheral blood SIRT1 mRNA levels in depression and treatment with electroconvulsive therapy.
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Authors
McGrory, Claire L
Ryan, Karen M
Kolshus, Erik
Finnegan, Martha
McLoughlin, Declan M
Issue Date
2018-07-13
Type
Journal Article
Pragmatic Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Pragmatic Clinical Trial
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Language
en
Keywords
Depression , Electroconvulsive therapy , Gene expression , SIRT1
Alternative Title
Abstract
Sirtuins are a family of nicotinamide adenine dinucleotide (NAD+) dependent enzymes that regulate cellular functions through deacetylation of protein targets. They have roles in both the periphery and central nervous system and have been implicated in depression biology. A recent genome-wide association study has identified a locus for major depression in the Sirtuin1 gene (SIRT1) and lower blood levels of SIRT1 mRNA in patients with depression have also been observed in two studies. To our knowledge, no studies have examined the effect of treatment on SIRT1 levels in patients with depression. We therefore examined SIRT1 mRNA levels in a well characterised group of patients with depression, compared to healthy controls, and characterised the effects of a course of electroconvulsive therapy (ECT) on peripheral blood SIRT1 mRNA. Depressed patients (n = 91) were matched to healthy controls (n = 85) on the basis of age and sex. In line with previous studies, blood SIRT1 mRNA levels were lower in depressed patients in comparison to controls (p = 0.005). However, ECT had no effect on SIRT1 levels (p = 0.67). There was no relationship between baseline pre-ECT SIRT1 levels and depression severity, change in mood scores, suicidality, depression polarity, presence of psychosis, or response to treatment. There was a trend for a negative association between an increase in SIRT1 mRNA and a decrease in HAM-D24 scores in ECT responders and remitters. These results indicate that reduced peripheral blood SIRT1 mRNA could be a trait feature of depression.
Description
Citation
McGrory, C. L., Ryan, K. M., Kolshus, E., Finnegan, M., & McLoughlin, D. M. (2018). Peripheral blood SIRT1 mRNA levels in depression and treatment with electroconvulsive therapy. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 28(9), 1015–1023. https://doi.org/10.1016/j.euroneuro.2018.06.007
Publisher
License
Copyright © 2018 Elsevier B.V. and ECNP. All rights reserved.
Journal
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Volume
28
Issue
9
PubMed ID
ISSN
1873-7862