Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder.
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Authors
Bauer, Michael
Glenn, Tasha
Achtyes, Eric D
Alda, Martin
Agaoglu, Esen
Altınbaş, Kürsat
Andreassen, Ole A
Angelopoulos, Elias
Ardau, Raffaella
Aydin, Memduha
Issue Date
2023-06-22
Type
Journal Article
Language
en
Keywords
Alternative Title
Abstract
Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.
Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001.
The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.
UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.
Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001.
The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.
UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.
Description
Citation
Bauer, M., Glenn, T., Achtyes, E. D., Alda, M., Agaoglu, E., Altınbaş, K., Andreassen, O. A., Angelopoulos, E., Ardau, R., Aydin, M., Ayhan, Y., Baethge, C., Bauer, R., Baune, B. T., Balaban, C., Becerra-Palars, C., Behere, A. P., Behere, P. B., Belete, H., Belete, T., … Whybrow, P. C. (2023). Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder. International journal of bipolar disorders, 11(1), 22. https://doi.org/10.1186/s40345-023-00303-w
Publisher
License
© 2023. The Author(s).
Journal
International journal of bipolar disorders
Volume
11
Issue
1
PubMed ID
DOI
10.1186/s40345-023-00303-w
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10.1038/s41893-019-0314-2
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10.1016/j.jpsychores.2022.110982
10.1517/14728222.2015.1018822
10.1111/j.1601-5215.2009.00402.x
10.1016/j.bbrc.2015.01.008
10.1124/pr.116.013227
10.1080/01616412.2019.1622872
10.1007/s11818-019-00215-x
10.1038/nrendo.2017.31
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10.1017/S1368980010002454
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10.1016/j.yfrne.2012.07.001
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10.1177/14771535211014792
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10.1002/jbm4.10417.PMID:33354643
10.4088/JCP.13r08507
10.1146/annurev-nutr-071813-105557
10.1093/ajcn/80.6.1678S
10.1007/s11154-017-9424-1
10.1073/pnas.0914628107
10.1111/bdi.12419
10.3238/arztebl.2017.0575
10.1038/nrn3743
10.1016/j.jpsychires.2017.07.021
10.1016/j.tins.2019.01.003
10.1111/j.1751-1097.2008.00400.x
10.1016/j.euroneuro.2022.06.004
10.1017/S0029665119001538
10.3390/nu8090533
10.1016/j.jsbmb.2013.11.003
10.1111/j.0006-341x.2001.00120.x
10.1096/fj.14-268342
10.1530/JOE-19-0302
10.1016/j.cub.2006
10.1016/j.cct.2008.04.003
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10.1111/pcn.12688
10.1210/jc.2014-1887
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10.1210/jcem-67-2-373
10.1175/1520-0477(1996)077<0853:CATERE>2.0.CO;2
10.1016/j.bcp.2020.114304
ISSN
2194-7511