Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy.
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Authors
Fenton, Caoimhe
McLoughlin, Declan M
Issue Date
2021-11-09
Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
We investigated the predictive value of subset scales and full versions of the Hamilton Rating Scale for Depression (HAMD) for therapeutic outcomes in ECT.
This secondary analysis of patients with major depression (N = 136; 63% female; age = 56.7 [SD = 14.8]) from the EFFECT-Dep trial (NCT01907217) examined the predictive value of Evans-6, Toronto-7, Gibbons-8 and Maier-Philip 6 HAMD subset scales and three 'full' versions (HAMD-17, HAMD-21 and HAMD-24) on therapeutic outcomes. We also examined early improvement on subset scales and full versions as predictors of response and remission and explored predictive abilities of individual HAMD-24 items.
The subset scales and full scales lacked sufficient predictive ability for response and remission. Receiver operating characteristic curves identified a lack of discriminative capacity of HAMD subset scales and full versions at baseline to predict response and remission. Only the Maier-Philip-6 was significantly associated with percentage reduction in HAMD-24 scores from baseline to end of ECT course. Early improvement on most of the subset scales and full versions was a sensitive and specific predictor of response and remission. Four of the HAMD-24 items were significantly associated with response and one with remission.
Limited utility of the HAMD subset scales and full versions in this context highlight a need for more tailored depression rating scales for ECT.
This secondary analysis of patients with major depression (N = 136; 63% female; age = 56.7 [SD = 14.8]) from the EFFECT-Dep trial (NCT01907217) examined the predictive value of Evans-6, Toronto-7, Gibbons-8 and Maier-Philip 6 HAMD subset scales and three 'full' versions (HAMD-17, HAMD-21 and HAMD-24) on therapeutic outcomes. We also examined early improvement on subset scales and full versions as predictors of response and remission and explored predictive abilities of individual HAMD-24 items.
The subset scales and full scales lacked sufficient predictive ability for response and remission. Receiver operating characteristic curves identified a lack of discriminative capacity of HAMD subset scales and full versions at baseline to predict response and remission. Only the Maier-Philip-6 was significantly associated with percentage reduction in HAMD-24 scores from baseline to end of ECT course. Early improvement on most of the subset scales and full versions was a sensitive and specific predictor of response and remission. Four of the HAMD-24 items were significantly associated with response and one with remission.
Limited utility of the HAMD subset scales and full versions in this context highlight a need for more tailored depression rating scales for ECT.
Description
Citation
Fenton, C., & McLoughlin, D. M. (2021). Usefulness of Hamilton rating scale for depression subset scales and full versions for electroconvulsive therapy. PloS one, 16(11), e0259861. https://doi.org/10.1371/journal.pone.0259861
Publisher
License
Journal
PloS one
Volume
16
Issue
11
PubMed ID
DOI
10.1371/journal.pone.0259861
10.1016/S0140-6736(03)12705-5
10.1017/S0033291716002737
10.1192/bjp.2017.28
10.1136/jnnp.23.1.56
10.1007/s00406-011-0263-x
10.1016/s0022-3956(02)00024-9
10.1176/appi.ajp.161.12.2163
10.1111/j.1600-0447.1981.tb00676.x
10.1016/j.jpsychires.2003.11.003
10.1503/cmaj.050786
10.1016/0022-3956(93)90037-3
10.1016/s0022-3956(99)00037-0
10.1016/j.jad.2014.12.043
10.1016/j.jad.2012.08.026
10.1016/j.jad.2019.04.082
10.1016/j.jad.2013.06.035
10.1097/YCT.0b013e3181b00f32
10.1176/appi.ajp.2015.15030372
10.1016/j.athoracsur.2015.11.024
10.1097/00005650-199303000-00006
10.1159/000506879
10.1037/pas0000275
10.1186/s12916-015-0325-4
10.1016/j.expneurol.2020.113505
10.4088/JCP.14r09528
10.1177/0269881120922950
10.1016/j.jad.2006.12.015
10.1016/j.jpsychires.2017.07.003
10.1016/j.jpsychires.2019.07.009
10.1016/S0140-6736(03)12705-5
10.1017/S0033291716002737
10.1192/bjp.2017.28
10.1136/jnnp.23.1.56
10.1007/s00406-011-0263-x
10.1016/s0022-3956(02)00024-9
10.1176/appi.ajp.161.12.2163
10.1111/j.1600-0447.1981.tb00676.x
10.1016/j.jpsychires.2003.11.003
10.1503/cmaj.050786
10.1016/0022-3956(93)90037-3
10.1016/s0022-3956(99)00037-0
10.1016/j.jad.2014.12.043
10.1016/j.jad.2012.08.026
10.1016/j.jad.2019.04.082
10.1016/j.jad.2013.06.035
10.1097/YCT.0b013e3181b00f32
10.1176/appi.ajp.2015.15030372
10.1016/j.athoracsur.2015.11.024
10.1097/00005650-199303000-00006
10.1159/000506879
10.1037/pas0000275
10.1186/s12916-015-0325-4
10.1016/j.expneurol.2020.113505
10.4088/JCP.14r09528
10.1177/0269881120922950
10.1016/j.jad.2006.12.015
10.1016/j.jpsychires.2017.07.003
10.1016/j.jpsychires.2019.07.009
ISSN
1932-6203