Dermatoglyphics and Schizophrenia: a meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count.
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Authors
Bramon, Elvira
Walshe, Muriel
McDonald, Colm
Martín, Beatriz
Toulopoulou, Timothea
Wickham, Harvey
van Os, Jim
Fearon, Paul
Sham, Pak C
Fañanás, Lourdes
Issue Date
2005-Jun-15
Type
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Meta-Analysis
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
Patients with schizophrenia show deviances in their dermatoglyphics, in particular reductions in palmar a-b ridge counts (ABRCs), which are evidence of an early developmental deviance. However, the severity or the origin of these ABRC changes has not been established.
(i) We examined the published literature on the ABRC in patients with schizophrenia against controls with a random effects meta-analysis. (ii) We used linear regression to study the ABRC in our sample of families including 125 patients with schizophrenia, 107 of their unaffected relatives and 98 controls. (iii) The effect of obstetric complications on the patient's ABRC was examined using the Lewis Murray scale.
The pooled standardised effect size of ABRC differences between patients and controls obtained by our meta-analysis was 0.39 (95% CI: 0.05-0.73; p=0.03). In our sample, there were no significant differences in ABRCs between those with schizophrenia, their relatives and controls. Only those patients with obstetric complications had significantly reduced ABRC compared to controls (p=0.01).
We confirmed the presence of significant yet mild ABRC reductions in schizophrenia. These represent a subtle deviance from the norm and could be present in certain subsets of patients, possibly those who suffered early developmental insults.
(i) We examined the published literature on the ABRC in patients with schizophrenia against controls with a random effects meta-analysis. (ii) We used linear regression to study the ABRC in our sample of families including 125 patients with schizophrenia, 107 of their unaffected relatives and 98 controls. (iii) The effect of obstetric complications on the patient's ABRC was examined using the Lewis Murray scale.
The pooled standardised effect size of ABRC differences between patients and controls obtained by our meta-analysis was 0.39 (95% CI: 0.05-0.73; p=0.03). In our sample, there were no significant differences in ABRCs between those with schizophrenia, their relatives and controls. Only those patients with obstetric complications had significantly reduced ABRC compared to controls (p=0.01).
We confirmed the presence of significant yet mild ABRC reductions in schizophrenia. These represent a subtle deviance from the norm and could be present in certain subsets of patients, possibly those who suffered early developmental insults.
Description
Citation
Bramon, E., Walshe, M., McDonald, C., Martín, B., Toulopoulou, T., Wickham, H., van Os, J., Fearon, P., Sham, P. C., Fañanás, L., & Murray, R. M. (2005). Dermatoglyphics and Schizophrenia: a meta-analysis and investigation of the impact of obstetric complications upon a-b ridge count. Schizophrenia research, 75(2-3), 399–404. https://doi.org/10.1016/j.schres.2004.08.022
Publisher
License
Journal
Schizophrenia research
Volume
75
Issue
2-3
PubMed ID
ISSN
0920-9964