Serum thyrotropin responses to thyrotropin-releasing hormone in alcohol-dependent patients with and without depression.
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Authors
O'Hanlon, M
Barry, S
Clare, A W
Dinan, T G
Issue Date
1991-Feb
Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
Forty-one patients with DSM-III alcohol dependence syndrome were studied, as were 30 patients with major depression and 20 healthy controls. Nineteen of the alcohol-dependent patients had depressive symptoms. All subjects underwent a TRH/TSH stimulation test. Fifty percent of the alcohol-dependent patients without depression had a blunted response, while 52% of patients with depression were similarly blunted. The overall rate of blunting in the non-alcoholic major depressives was 26%. Blunting in the alcoholics was not associated with a personal or family history of affective disorder. Furthermore the blunted response in recently detoxified alcoholics was of no prognostic significance.
Description
Citation
O'Hanlon, M., Barry, S., Clare, A. W., & Dinan, T. G. (1991). Serum thyrotropin responses to thyrotropin-releasing hormone in alcohol-dependent patients with and without depression. Journal of affective disorders, 21(2), 109–115. https://doi.org/10.1016/0165-0327(91)90057-y
Publisher
License
Journal
Journal of affective disorders
Volume
21
Issue
2
PubMed ID
ISSN
0165-0327