The Ketamine Side Effect Tool (KSET): A comprehensive measurement-based safety tool for ketamine treatment in psychiatry.
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Authors
Bayes, Adam
Short, Brooke
Zarate, Carlos A
Park, Lawrence
Murrough, James W
McLoughlin, Declan M
Riva-Posse, Patricio
Schoevers, Robert
Veraart, Jolien
Parikh, Sagar
Issue Date
2022-04-09
Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Language
en
Keywords
Antidepressant , Maintenance , Safety , Side effects
Alternative Title
Abstract
On a background of the rapidly expanding clinical use of ketamine and esketamine for treatment of depression and other conditions, we examined safety monitoring, seeking to identify knowledge gaps relevant to clinical practice.
An international group of psychiatrists discussed the issue of safety of ketamine and esketamine and came to a consensus on key safety gaps.
There is no standard safety monitoring for off-label generic ketamine. For intranasal esketamine, each jurisdiction providing regulatory approval may specify monitoring. Treatment is often provided beyond the period for which safety has been demonstrated, with no agreed framework for monitoring of longer term side effects for either generic ketamine or intranasal esketamine.
The KSET has established face and content validity, however it has not been validated against other measures of safety.
We recommend the Ketamine Side Effect Tool (KSET) as a comprehensive safety monitoring tool for acute and longer term side effects.
An international group of psychiatrists discussed the issue of safety of ketamine and esketamine and came to a consensus on key safety gaps.
There is no standard safety monitoring for off-label generic ketamine. For intranasal esketamine, each jurisdiction providing regulatory approval may specify monitoring. Treatment is often provided beyond the period for which safety has been demonstrated, with no agreed framework for monitoring of longer term side effects for either generic ketamine or intranasal esketamine.
The KSET has established face and content validity, however it has not been validated against other measures of safety.
We recommend the Ketamine Side Effect Tool (KSET) as a comprehensive safety monitoring tool for acute and longer term side effects.
Description
Citation
Bayes, A., Short, B., Zarate, C. A., Park, L., Murrough, J. W., McLoughlin, D. M., Riva-Posse, P., Schoevers, R., Veraart, J., Parikh, S., Glue, P., Fam, J., McShane, R., Galvez, V., Martin, D., Tor, P. C., Brunoni, A. R., & Loo, C. K. (2022). The Ketamine Side Effect Tool (KSET): A comprehensive measurement-based safety tool for ketamine treatment in psychiatry. Journal of affective disorders, 308, 44–46. https://doi.org/10.1016/j.jad.2022.04.020
Publisher
License
Copyright © 2022 Elsevier B.V. All rights reserved.
Journal
Journal of affective disorders
Volume
308
Issue
PubMed ID
ISSN
1573-2517