Effectiveness of a tailored, integrative Internet intervention (deprexis) for depression: Updated meta-analysis.

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Twomey, Conal
O'Reilly, Gary
Bültmann, Oliver
Meyer, Björn

Issue Date

2020-01-30

Type

Journal Article
Meta-Analysis

Language

en

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Abstract

Digitally delivered interventions for depression vary in many aspects, including their therapeutic orientation, depth of content, interactivity, individual tailoring, inclusion of multimedia, cost, and effectiveness. However, their effectiveness is rarely examined in intervention-specific meta-analyses. An earlier meta-analysis of eight randomized controlled trials (RCT) demonstrated the effectiveness of a tailored, integrative digital intervention (deprexis), which is delivered via the Internet. This updated meta-analysis of twelve deprexis-specific RCT with a total of N = 2901 participants confirmed the effectiveness of deprexis for depression reduction at post-intervention (g = 0.51, 95% CI: 0.40-0.62, I2 = 26%). Results were analogous when study quality, screening and randomization procedure were taken into account. Clinician guidance, developer-involvement, setting (community vs. clinical), and initial symptom severity did not have statistically significant effects on the effect size, and there was no evidence of publication bias. Thus, these findings demonstrate that deprexis can facilitate clinically relevant reduction of depressive symptoms over 8-12 weeks across a broad range of initial symptom severity, and that the intervention can be combined with other forms of depression treatment. There is now a need to study the intervention's implementation in routine care settings as well as its long-term effectiveness and cost-effectiveness in diverse cultural and linguistic settings.

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Twomey, C., O'Reilly, G., Bültmann, O., & Meyer, B. (2020). Effectiveness of a tailored, integrative Internet intervention (deprexis) for depression: Updated meta-analysis. PloS one, 15(1), e0228100. https://doi.org/10.1371/journal.pone.0228100

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PloS one

Volume

15

Issue

1

URI

https://repository.stpatricks.ie/handle/internal/259

PubMed ID

31999743

DOI

10.1371/journal.pone.0228100
10.1016/S2215-0366(16)30024-4
10.1001/jamapsychiatry.2017.0044
10.2196/jmir.3147
10.1136/bmj.h5627
10.1002/da.22249
10.2196/jmir.1151
10.1016/S2215-0366(17)30153-0
10.1111/acps.12275
10.1016/j.psychres.2017.08.033
10.1111/j.0006-341x.2000.00455.x
10.1080/16506073.2011.616531
10.1016/j.jad.2017.11.021
10.1371/journal.pone.0198859
10.1016/S2215-0366(14)00049-2
10.1055/s-0043-122241
10.1159/000445355
10.1111/epi.12833
10.1159/000481177
10.3758/bf03193146
10.2196/13655
10.1136/bmj.f540
10.1016/S0140-6736(08)61764-X
10.1037/bul0000015
10.1016/j.invent.2014.08.003
10.1159/000441951
10.1016/j.janxdis.2015.08.002
10.1017/S2045796018000057
10.1192/bjp.bp.109.066001
10.1017/S0033291709006114
10.1056/NEJMsa065779
10.1371/journal.pone.0098118
10.1016/S1474-4422(16)00066-1
10.1016/bs.irn.2018.01.013
10.1017/S0033291715000665
10.1016/j.jad.2017.12.028
10.1186/s13561-019-0233-y
10.1136/bmjopen-2016-015391
10.1016/j.brat.2017.07.013
10.1002/da.22727

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1932-6203

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