Gender differences in neuropsychological performance across psychotic disorders--a multi-centre population based case-control study.
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Authors
Zanelli, Jolanta
Morgan, Kevin
Dazzan, Paola
Morgan, Craig
Russo, Manuela
Pilecka, Izabela
Fearon, Paul
Demjaha, Arsime
Doody, Gill A
Jones, Peter B
Issue Date
2013-10-28
Type
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Multicenter Study
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
Patients with schizophrenia and other psychoses exhibit a wide range of neuropsychological deficits. An unresolved question concerns whether there are gender differences in cognitive performance.
Data were derived from a multi-centre population based case-control study of patients with first-episode psychosis. A neuropsychological test battery was administered to patients with a diagnosis of schizophrenia or schizoaffective disorder (N=70, 36% females), bipolar/mania (N=34, 60% females), depressive psychosis (N=36, 58% females) and healthy controls (N=148, 55% females). Generalized and specific cognitive deficits were compared.
There was strong evidence for disorder-specific gender differences in neuropsychological performance. Males and females with schizophrenia showed similar pervasive neuropsychological impairments. In psychotic depressive disorder females performed worse than males across neuropsychological measures. Differences in neuropsychological performance between males and females with bipolar/manic disorder were restricted to language functions. Symptom severity did not contribute to the observed gender differences.
Early in the course of psychotic illness, gender related factors appear to moderate the severity of cognitive deficits in depressive psychosis and bipolar/mania patients.
Data were derived from a multi-centre population based case-control study of patients with first-episode psychosis. A neuropsychological test battery was administered to patients with a diagnosis of schizophrenia or schizoaffective disorder (N=70, 36% females), bipolar/mania (N=34, 60% females), depressive psychosis (N=36, 58% females) and healthy controls (N=148, 55% females). Generalized and specific cognitive deficits were compared.
There was strong evidence for disorder-specific gender differences in neuropsychological performance. Males and females with schizophrenia showed similar pervasive neuropsychological impairments. In psychotic depressive disorder females performed worse than males across neuropsychological measures. Differences in neuropsychological performance between males and females with bipolar/manic disorder were restricted to language functions. Symptom severity did not contribute to the observed gender differences.
Early in the course of psychotic illness, gender related factors appear to moderate the severity of cognitive deficits in depressive psychosis and bipolar/mania patients.
Description
Citation
Zanelli, J., Morgan, K., Dazzan, P., Morgan, C., Russo, M., Pilecka, I., Fearon, P., Demjaha, A., Doody, G. A., Jones, P. B., Murray, R. M., & Reichenberg, A. (2013). Gender differences in neuropsychological performance across psychotic disorders--a multi-centre population based case-control study. PloS one, 8(10), e77318. https://doi.org/10.1371/journal.pone.0077318
Publisher
License
Journal
PloS one
Volume
8
Issue
10
PubMed ID
DOI
10.1371/journal.pone.0077318
10.1016/S0006-3223(00)01120-3
10.1016/j.psychres.2008.01.012
10.1038/sj.npp.1301395
10.1176/appi.ajp.2009.09010118
10.1093/schbul/sbn044
10.1016/0920-9964(92)90062-A
10.1097/00005053-199508000-00005
10.1001/archpsyc.57.8.769
10.1016/0920-9964(91)90142-E
10.1093/schbul/16.2.255
10.1016/S0006-3223(97)87315-5
10.1017/S0033291709991644
10.1111/j.1399-5618.2008.00592.x
10.1001/archpsyc.1990.01810180089012
10.1017/S0033291709990651
10.1037/0033-2909.133.5.833
10.1016/j.biopsych.2008.04.005
10.1176/appi.ajp.2010.09070937
10.1038/nn.2572
10.1001/archpsyc.57.6.593
10.1016/j.schres.2009.12.009
10.1016/S0006-3223(00)01120-3
10.1016/j.psychres.2008.01.012
10.1038/sj.npp.1301395
10.1176/appi.ajp.2009.09010118
10.1093/schbul/sbn044
10.1016/0920-9964(92)90062-A
10.1097/00005053-199508000-00005
10.1001/archpsyc.57.8.769
10.1016/0920-9964(91)90142-E
10.1093/schbul/16.2.255
10.1016/S0006-3223(97)87315-5
10.1017/S0033291709991644
10.1111/j.1399-5618.2008.00592.x
10.1001/archpsyc.1990.01810180089012
10.1017/S0033291709990651
10.1037/0033-2909.133.5.833
10.1016/j.biopsych.2008.04.005
10.1176/appi.ajp.2010.09070937
10.1038/nn.2572
10.1001/archpsyc.57.6.593
10.1016/j.schres.2009.12.009
ISSN
1932-6203