An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.
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Authors
Lau, Kwok-Fai
Perkinton, Michael S
Rodriguez, Lilia
McLoughlin, Declan M
Miller, Christopher C J
Issue Date
2010-Aug-04
Type
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Language
en
Keywords
Alternative Title
Abstract
X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains. X11alpha also contains two C-terminal postsynaptic density-95, large discs, zona occludens 1 (PDZ) domains, and we show here that through its PDZ domains, X11alpha interacts with a novel transcription factor, fibrinogen silencer binding protein. Moreover, we show that an X11alpha/fibrinogen silencer binding protein complex signals to the nucleus to repress glycogen synthase kinase-3beta promoter activity. Glycogen synthase kinase-3beta is a favoured candidate kinase for phosphorylating tau in Alzheimer's disease. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.
Description
Citation
Lau, K. F., Perkinton, M. S., Rodriguez, L., McLoughlin, D. M., & Miller, C. C. (2010). An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter. Neuroreport, 21(11), 761–766. https://doi.org/10.1097/WNR.0b013e32833bfca0
Publisher
License
Journal
Neuroreport
Volume
21
Issue
11
PubMed ID
ISSN
1473-558X